HIV-1 and HIV-2 in Spain.

Molecular Epidemiology of HIV-1 in Afghanistan, Iran, and Pakistan

We conducted this study to obtain a comprehensive picture of molecular epidemiology of HIV-1 in three neighboring countries, i.e. Afghanistan, Iran, and Pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. Our results showed that subtype composition differs between these countries with more variation in Pakistan than Iran and Afghanistan. The CRF3...

MOLECULAR BIOLOGY OF HUMAN IMMUNODEFICIENCY VIRUSES: HIV-l AND HIV-2

Intersubtype Recombination in HIV-1 and HIV-2

Recombination has long been known to represent an important means by which retroviruses generate genetic diversity. Each retrovirus particle contains a dimeric RNA genome and a reverse transcriptase enzyme that can switch templates during proviral DNA synthesis. Several mechanisms have been proposed to explain the recombination process, all of which are believed to operate during the reverse tr...

Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...

No Role of Herpes Simplex Virus Type 2 (HSV-2) Infection on HIV Progression in Naïve HIV Patients

Background: Herpes simplex virus type 2 (HSV-2) is a common infection in human immunodeficiency virus (HIV) patients and may accelerate HIV progression by rising HIV viral load and decreasing CD4 count. However, the available data regarding the influence of HSV-2 seropositivity on HIV progression in HIV individuals are inconclusive. Therefore, we aimed to determine HSV-2 seroprevalence in na&iu...